The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes. It remains an unanswered evolutionary question as to h...

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Bibliographic Details
Main Authors: Braulio Bonilla, Alexander J Brown, Sarah R Hengel, Kyle S Rapchak, Debra Mitchell, Catherine A Pressimone, Adeola A Fagunloye, Thong T Luong, Reagan A Russell, Rudri K Vyas, Tony M Mertz, Hani S Zaher, Nima Mosammaparast, Ewa P Malc, Piotr A Mieczkowski, Steven A Roberts, Kara A Bernstein
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
Rad51 paralogs
Shu complex
DNA repair
alkyation damage
homologous recombination
Rad51
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77
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https://doaj.org/article/3c12084a8dba4d91b827c88a4ddb1f77

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