Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
Chiral α-aryl ketones are versatile building blocks, and represent important pharmacophores existing in many drug molecules such as ibuprofen and naproxen. Here the authors for such ketones but using nickel and photoredox dual catalysis in asymmetric benzylic C−H acylation of alkylarenes and employi...
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| Main Authors: | , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/3c17fee165d643adbb5f5970a04f1828 |
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| Summary: | Chiral α-aryl ketones are versatile building blocks, and represent important pharmacophores existing in many drug molecules such as ibuprofen and naproxen. Here the authors for such ketones but using nickel and photoredox dual catalysis in asymmetric benzylic C−H acylation of alkylarenes and employing carboxylic acids as acyl surrogates. |
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