Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis

Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis

Chiral α-aryl ketones are versatile building blocks, and represent important pharmacophores existing in many drug molecules such as ibuprofen and naproxen. Here the authors for such ketones but using nickel and photoredox dual catalysis in asymmetric benzylic C−H acylation of alkylarenes and employi...

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Autores principales: Leitao Huan, Xiaomin Shu, Weisai Zu, De Zhong, Haohua Huo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/3c17fee165d643adbb5f5970a04f1828
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spelling oai:doaj.org-article:3c17fee165d643adbb5f5970a04f18282021-12-02T17:30:39ZAsymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis10.1038/s41467-021-23887-22041-1723https://doaj.org/article/3c17fee165d643adbb5f5970a04f18282021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23887-2https://doaj.org/toc/2041-1723Chiral α-aryl ketones are versatile building blocks, and represent important pharmacophores existing in many drug molecules such as ibuprofen and naproxen. Here the authors for such ketones but using nickel and photoredox dual catalysis in asymmetric benzylic C−H acylation of alkylarenes and employing carboxylic acids as acyl surrogates.Leitao HuanXiaomin ShuWeisai ZuDe ZhongHaohua HuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Leitao Huan
Xiaomin Shu
Weisai Zu
De Zhong
Haohua Huo
Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
description Chiral α-aryl ketones are versatile building blocks, and represent important pharmacophores existing in many drug molecules such as ibuprofen and naproxen. Here the authors for such ketones but using nickel and photoredox dual catalysis in asymmetric benzylic C−H acylation of alkylarenes and employing carboxylic acids as acyl surrogates.
format article
author Leitao Huan
Xiaomin Shu
Weisai Zu
De Zhong
Haohua Huo
author_facet Leitao Huan
Xiaomin Shu
Weisai Zu
De Zhong
Haohua Huo
author_sort Leitao Huan
title Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
title_short Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
title_full Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
title_fullStr Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
title_full_unstemmed Asymmetric benzylic C(sp3)−H acylation via dual nickel and photoredox catalysis
title_sort asymmetric benzylic c(sp3)−h acylation via dual nickel and photoredox catalysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3c17fee165d643adbb5f5970a04f1828
work_keys_str_mv AT leitaohuan asymmetricbenzyliccsp3hacylationviadualnickelandphotoredoxcatalysis
AT xiaominshu asymmetricbenzyliccsp3hacylationviadualnickelandphotoredoxcatalysis
AT weisaizu asymmetricbenzyliccsp3hacylationviadualnickelandphotoredoxcatalysis
AT dezhong asymmetricbenzyliccsp3hacylationviadualnickelandphotoredoxcatalysis
AT haohuahuo asymmetricbenzyliccsp3hacylationviadualnickelandphotoredoxcatalysis
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