JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression

LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to induce subsequent epithelial cells transformation a...

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Autores principales:	Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, Francesco J. DeMayo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3c4a64d307334e7da067be3231521b05
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spelling	oai:doaj.org-article:3c4a64d307334e7da067be3231521b052021-12-02T17:01:33ZJNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression10.1038/s41467-019-09843-12041-1723https://doaj.org/article/3c4a64d307334e7da067be3231521b052019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09843-1https://doaj.org/toc/2041-1723LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to induce subsequent epithelial cells transformation and tumour progression.Jian LiuTianyuan WangChad J. CreightonSan-Pin WuMadhumita RayKyathanahalli S. JanardhanCynthia J. WillsonSung-Nam ChoPatricia D. CastroMichael M. IttmannJian-Liang LiRoger J. DavisFrancesco J. DeMayoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Liu Tianyuan Wang Chad J. Creighton San-Pin Wu Madhumita Ray Kyathanahalli S. Janardhan Cynthia J. Willson Sung-Nam Cho Patricia D. Castro Michael M. Ittmann Jian-Liang Li Roger J. Davis Francesco J. DeMayo JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
description	LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to induce subsequent epithelial cells transformation and tumour progression.
format	article
author	Jian Liu Tianyuan Wang Chad J. Creighton San-Pin Wu Madhumita Ray Kyathanahalli S. Janardhan Cynthia J. Willson Sung-Nam Cho Patricia D. Castro Michael M. Ittmann Jian-Liang Li Roger J. Davis Francesco J. DeMayo
author_facet	Jian Liu Tianyuan Wang Chad J. Creighton San-Pin Wu Madhumita Ray Kyathanahalli S. Janardhan Cynthia J. Willson Sung-Nam Cho Patricia D. Castro Michael M. Ittmann Jian-Liang Li Roger J. Davis Francesco J. DeMayo
author_sort	Jian Liu
title	JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
title_short	JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
title_full	JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
title_fullStr	JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
title_full_unstemmed	JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression
title_sort	jnk1/2 represses lkb 1-deficiency-induced lung squamous cell carcinoma progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3c4a64d307334e7da067be3231521b05
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JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression

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