Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers

por Fengju Chen, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton
Publicado 2019

Global molecular alterations involving recurrence or progression of pediatric brain tumors

por Fengju Chen, Darshan S. Chandrashekar, Michael E. Scheurer, Sooryanarayana Varambally, Chad J. Creighton
Publicado 2022

A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

por Yiqun Zhang, Fengju Chen, Lawrence A. Donehower, Michael E. Scheurer, Chad J. Creighton
Publicado 2021

Meta-analysis of host transcriptional responses to SARS-CoV-2 infection reveals their manifestation in human tumors

por Fengju Chen, Yiqun Zhang, Richard Sucgang, Sasirekha Ramani, David Corry, Farrah Kheradmand, Chad J. Creighton
Publicado 2021

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

por Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Publicado 2018

Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer

por Shih-Chieh Lin, Chung-Yang Kao, Hui-Ju Lee, Chad J. Creighton, Michael M. Ittmann, Shaw-Jenq Tsai, Sophia Y. Tsai, Ming-Jer Tsai
Publicado 2016

A genetic cell context-dependent role for ZEB1 in lung cancer

por Ting Zhang, Lixia Guo, Chad J. Creighton, Qiang Lu, Don L. Gibbons, Eunhee S. Yi, Bo Deng, Julian R. Molina, Zhifu Sun, Ping Yang, Yanan Yang
Publicado 2016

Pan-urologic cancer genomic subtypes that transcend tissue of origin

por Fengju Chen, Yiqun Zhang, Dominick Bossé, Aly-Khan A. Lalani, A. Ari Hakimi, James J. Hsieh, Toni K. Choueiri, Don L. Gibbons, Michael Ittmann, Chad J. Creighton
Publicado 2017

Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy

por Yiqun Zhang, Fengju Chen, Erin Pleasance, Laura Williamson, Cameron J. Grisdale, Emma Titmuss, Janessa Laskin, Steven J.M. Jones, Isidro Cortes-Ciriano, Marco A. Marra, Chad J. Creighton
Publicado 2021

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

por Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brazma, PCAWG Transcriptome Working Group, PCAWG Structural Variation Working Group, Chad J. Creighton, PCAWG Consortium
Publicado 2020

JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression

por Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, Francesco J. DeMayo
Publicado 2019

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

por Priyam Banerjee, Guan-Yu Xiao, Xiaochao Tan, Veronica J. Zheng, Lei Shi, Maria Neus Bota Rabassedas, Hou-fu Guo, Xin Liu, Jiang Yu, Lixia Diao, Jing Wang, William K. Russell, Jason Roszik, Chad J. Creighton, Jonathan M. Kurie
Publicado 2021

Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis

por Diana Monsivais, Takashi Nagashima, Renata Prunskaite-Hyyryläinen, Kaori Nozawa, Keisuke Shimada, Suni Tang, Clark Hamor, Julio E. Agno, Fengju Chen, Ramya P. Masand, Steven L. Young, Chad J. Creighton, Francesco J. DeMayo, Masahito Ikawa, Se-Jin Lee, Martin M. Matzuk
Publicado 2021

ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

por Roxsan Manshouri, Etienne Coyaud, Samrat T. Kundu, David H. Peng, Sabrina A. Stratton, Kendra Alton, Rakhee Bajaj, Jared J. Fradette, Rosalba Minelli, Michael D. Peoples, Alessandro Carugo, Fengju Chen, Christopher Bristow, Jeffrey J. Kovacs, Michelle C. Barton, Tim Heffernan, Chad J. Creighton, Brian Raught, Don L. Gibbons
Publicado 2019

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

por Jody Vykoukal, Johannes F. Fahrmann, Justin R. Gregg, Zhe Tang, Spyridon Basourakos, Ehsan Irajizad, Sanghee Park, Guang Yang, Chad J. Creighton, Alia Fleury, Jeffrey Mayo, Adriana Paulucci-Holthauzen, Jennifer B. Dennison, Eunice Murage, Christine B. Peterson, John W. Davis, Jeri Kim, Samir Hanash, Timothy C. Thompson
Publicado 2020

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

por Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Publicado 2018

In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer

por Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda, Karina Eterovic, Jared J. Fradette, Sumreen Ahmad, Fengju Chen, Zechen Chong, Ken Chen, Chad J. Creighton, Haian Fu, Gordon B. Mills, Don L. Gibbons, Kenneth L. Scott
Publicado 2018

Thy-1+ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis

por Mark J. Schliekelman, Chad J. Creighton, Brandi N. Baird, Yulong Chen, Priyam Banerjee, Neus Bota-Rabassedas, Young-Ho Ahn, Jonathon D. Roybal, Fengju Chen, Yiqun Zhang, Dhruva K. Mishra, Min P. Kim, Xin Liu, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio I. Wistuba, Samir M. Hanash, Jonathan M. Kurie
Publicado 2017

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice

por Hou-Fu Guo, Neus Bota-Rabassedas, Masahiko Terajima, B. Leticia Rodriguez, Don L. Gibbons, Yulong Chen, Priyam Banerjee, Chi-Lin Tsai, Xiaochao Tan, Xin Liu, Jiang Yu, Michal Tokmina-Roszyk, Roma Stawikowska, Gregg B. Fields, Mitchell D. Miller, Xiaoyan Wang, Juhoon Lee, Kevin N. Dalby, Chad J. Creighton, George N. Phillips, John A. Tainer, Mitsuo Yamauchi, Jonathan M. Kurie
Publicado 2021

Functional annotation of rare gene aberration drivers of pancreatic cancer

por Yiu Huen Tsang, Turgut Dogruluk, Philip M. Tedeschi, Joanna Wardwell-Ozgo, Hengyu Lu, Maribel Espitia, Nikitha Nair, Rosalba Minelli, Zechen Chong, Fengju Chen, Qing Edward Chang, Jennifer B. Dennison, Armel Dogruluk, Min Li, Haoqiang Ying, Joseph R. Bertino, Marie-Claude Gingras, Michael Ittmann, John Kerrigan, Ken Chen, Chad J. Creighton, Karina Eterovic, Gordon B. Mills, Kenneth L. Scott
Publicado 2016