Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors

Oncoprotein expression is controlled at the level of mRNA translation and is regulated by the eukaryotic translation initiation factor 4F (eIF4F) complex. eIF4A, a component of eIF4F, catalyzes the unwinding of secondary structure in the 5’-untranslated region (5’-UTR) of mRNA to facilitate ribosome...

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Autores principales: Adina Gerson-Gurwitz, Nathan P. Young, Vikas K. Goel, Boreth Eam, Craig R. Stumpf, Joan Chen, Sarah Fish, Maria Barrera, Eric Sung, Jocelyn Staunton, Gary G. Chiang, Kevin R. Webster, Peggy A. Thompson
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
zotatifin
eIF4A
PI3K
AKT
mTOR
receptor tyrosine kinase
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/3c591166c36f4888bb12e979b6ceb351
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https://doaj.org/article/3c591166c36f4888bb12e979b6ceb351

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