Inhibition of microRNA-494-3p activates Wntsignaling and reduces proinflammatorymacrophage polarization in atherosclerosis

We have previously shown that treatment with third-generation antisense oligonucleotides against miR-494-3p (3GA-494) reduces atherosclerotic plaque progression and stabilizes lesions, both in early and established plaques, with reduced macrophage content in established plaques. Within the plaque, d...

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Auteurs principaux: Eva van Ingen, Amanda C. Foks, Tamar Woudenberg, M. Leontien van der Bent, Alwin de Jong, Philipp J. Hohensinner, Johann Wojta, Ilze Bot, Paul.H.A. Quax, Anne Yaël Nossent
Format: article
Langue:EN
Publié: Elsevier 2021
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Accès en ligne:https://doaj.org/article/3c732ba897314891bf7651163691b08a
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