MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

MSI2 is required for maintaining activated myelodysplastic syndrome stem cells

Several studies have recently demonstrated the role of the MSI2 RNA binding protein in normal and malignant haematopoietc stem cells. In this study, the authors show that MSI2 is required for maintaining myelodysplastic syndrome stem cells in mice and that MSI2 expression predicts poor prognosis in...

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Main Authors: James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S. Barlowe, Alexendar R. Perez, Benjamin H. Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J. Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M. Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D. Nimer, Michael G. Kharas
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/3c73f9725b9740dfbe30b10dcaac4d49
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