Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Abstract Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo. To obtain agents capable of sequestering multiple TGF-β superfamily ligan...

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Main Authors: Ravindra Kumar, Asya V. Grinberg, Huiming Li, Tzu-Hsing Kuo, Dianne Sako, Lavanya Krishnan, Katia Liharska, Jia Li, Rosa Grenha, Michelle C. Maguire, Steven D. Briscoe, R. Scott Pearsall, Brantley R. Herrin, Rajasekhar N. V. S. Suragani, Roselyne Castonguay
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/3cc08f92090942b6b1e99a5715b4ec9a
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https://doaj.org/article/3cc08f92090942b6b1e99a5715b4ec9a

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