Increased Post-Hypoxic Oxidative Stress and Activation of the PERK Branch of the UPR in <i>Trap1</i>-Deficient <i>Drosophila melanogaster</i> Is Abrogated by Metformin
Hypoxia is known to impair mitochondrial and endoplasmic reticulum (ER) homeostasis. Post-hypoxic perturbations of the ER proteostasis result in the accumulation of misfolded/unfolded proteins leading to the activation of the Unfolded Protein Response (UPR). Mitochondrial chaperone TNF receptor-asso...
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Autores principales: | , , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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MDPI AG
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/3cdab83c92fd4d1aa7fe84e7ac3cdbdd |
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