Increased Post-Hypoxic Oxidative Stress and Activation of the PERK Branch of the UPR in <i>Trap1</i>-Deficient <i>Drosophila melanogaster</i> Is Abrogated by Metformin

Hypoxia is known to impair mitochondrial and endoplasmic reticulum (ER) homeostasis. Post-hypoxic perturbations of the ER proteostasis result in the accumulation of misfolded/unfolded proteins leading to the activation of the Unfolded Protein Response (UPR). Mitochondrial chaperone TNF receptor-asso...

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Autores principales: Alma Kokott-Vuong, Jennifer Jung, Aaron T. Fehr, Nele Kirschfink, Rozina Noristani, Aaron Voigt, Arno Reich, Jörg B. Schulz, Michael Huber, Pardes Habib
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
ROS
Acceso en línea:https://doaj.org/article/3cdab83c92fd4d1aa7fe84e7ac3cdbdd
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