Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins.
Botulinum neurotoxins (BoNTs) are the most potent toxins known and are also utilized to treat a wide range of disorders including muscle spasm, overactive bladder, and pain. BoNTs' ability to target neurons determines their specificity, potency, and therapeutic efficacy. Homologous synaptic ves...
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Auteurs principaux: | , , , , , , , , |
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Format: | article |
Langue: | EN |
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Public Library of Science (PLoS)
2021
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Accès en ligne: | https://doaj.org/article/3cf69e782b1546cfb49dd11df51d67a4 |
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