Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tum...

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Autores principales:	Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3d1388c6f86c4110af3e985cacb07322
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:3d1388c6f86c4110af3e985cacb073222021-12-02T16:08:14ZTumors induce de novo steroid biosynthesis in T cells to evade immunity10.1038/s41467-020-17339-62041-1723https://doaj.org/article/3d1388c6f86c4110af3e985cacb073222020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17339-6https://doaj.org/toc/2041-1723Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tumor growth.Bidesh MahataJhuma PramanikLouise van der WeydenKrzysztof PolanskiGozde KarAngela RiedelXi ChenNuno A. FonsecaKousik KunduLia S. CamposEdward RyderGraham DuddyIzabela WalczakKlaus OkkenhaugDavid J. AdamsJacqueline D. ShieldsSarah A. TeichmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bidesh Mahata Jhuma Pramanik Louise van der Weyden Krzysztof Polanski Gozde Kar Angela Riedel Xi Chen Nuno A. Fonseca Kousik Kundu Lia S. Campos Edward Ryder Graham Duddy Izabela Walczak Klaus Okkenhaug David J. Adams Jacqueline D. Shields Sarah A. Teichmann Tumors induce de novo steroid biosynthesis in T cells to evade immunity
description	Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tumor growth.
format	article
author	Bidesh Mahata Jhuma Pramanik Louise van der Weyden Krzysztof Polanski Gozde Kar Angela Riedel Xi Chen Nuno A. Fonseca Kousik Kundu Lia S. Campos Edward Ryder Graham Duddy Izabela Walczak Klaus Okkenhaug David J. Adams Jacqueline D. Shields Sarah A. Teichmann
author_facet	Bidesh Mahata Jhuma Pramanik Louise van der Weyden Krzysztof Polanski Gozde Kar Angela Riedel Xi Chen Nuno A. Fonseca Kousik Kundu Lia S. Campos Edward Ryder Graham Duddy Izabela Walczak Klaus Okkenhaug David J. Adams Jacqueline D. Shields Sarah A. Teichmann
author_sort	Bidesh Mahata
title	Tumors induce de novo steroid biosynthesis in T cells to evade immunity
title_short	Tumors induce de novo steroid biosynthesis in T cells to evade immunity
title_full	Tumors induce de novo steroid biosynthesis in T cells to evade immunity
title_fullStr	Tumors induce de novo steroid biosynthesis in T cells to evade immunity
title_full_unstemmed	Tumors induce de novo steroid biosynthesis in T cells to evade immunity
title_sort	tumors induce de novo steroid biosynthesis in t cells to evade immunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3d1388c6f86c4110af3e985cacb07322
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Tumors induce de novo steroid biosynthesis in T cells to evade immunity

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