Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment

Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment

Abstract Secretory lysosomes are required for the specialised functions of various types of differentiated cells. In osteoclasts, the lysosomal proton pump V-ATPase (vacuolar-type ATPase) is targeted to the plasma membrane via secretory lysosomes and subsequently acidifies the extracellular compartm...

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Main Authors: Naomi Matsumoto, Mizuki Sekiya, Koujiro Tohyama, Eri Ishiyama-Matsuura, Ge-Hong Sun-Wada, Yoh Wada, Masamitsu Futai, Mayumi Nakanishi-Matsui
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/3d1d5a34a2cd40518eac163e08643f18
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