GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection.
The reversible phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha) is a well-characterized mechanism of translational control in response to a wide variety of cellular stresses, including viral infection. Beside PKR, the eIF2alpha kinase GCN2 participates i...
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Autores principales: | Javier del Pino, José Luis Jiménez, Iván Ventoso, Alfredo Castelló, Ma Ángeles Muñoz-Fernández, César de Haro, Juan José Berlanga |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/3dad714f473849a4a52310c241437ed1 |
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