Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

Despite its wide and growing use, the mechanisms by which in vivo vagus nerve stimulation (VNS) exerts its therapeutic benefits are still largely unknown. Here, the authors show in mice that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by...

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Main Authors:	Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/3db00c7d3a824037b42b74b1d64db6e3
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spelling	oai:doaj.org-article:3db00c7d3a824037b42b74b1d64db6e32021-12-02T13:14:59ZGraded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve10.1038/s41467-021-21730-22041-1723https://doaj.org/article/3db00c7d3a824037b42b74b1d64db6e32021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21730-2https://doaj.org/toc/2041-1723Despite its wide and growing use, the mechanisms by which in vivo vagus nerve stimulation (VNS) exerts its therapeutic benefits are still largely unknown. Here, the authors show in mice that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine.Zakir MridhaJan Willem de GeeYanchen ShiRayan AlkashgariJustin WilliamsAaron SuminskiMatthew P. WardWenhao ZhangMatthew James McGinleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zakir Mridha Jan Willem de Gee Yanchen Shi Rayan Alkashgari Justin Williams Aaron Suminski Matthew P. Ward Wenhao Zhang Matthew James McGinley Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
description	Despite its wide and growing use, the mechanisms by which in vivo vagus nerve stimulation (VNS) exerts its therapeutic benefits are still largely unknown. Here, the authors show in mice that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine.
format	article
author	Zakir Mridha Jan Willem de Gee Yanchen Shi Rayan Alkashgari Justin Williams Aaron Suminski Matthew P. Ward Wenhao Zhang Matthew James McGinley
author_facet	Zakir Mridha Jan Willem de Gee Yanchen Shi Rayan Alkashgari Justin Williams Aaron Suminski Matthew P. Ward Wenhao Zhang Matthew James McGinley
author_sort	Zakir Mridha
title	Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
title_short	Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
title_full	Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
title_fullStr	Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
title_full_unstemmed	Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
title_sort	graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3db00c7d3a824037b42b74b1d64db6e3
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Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

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