Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences in the human microglial transcriptome between grey...

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Auteurs principaux:	Marlijn van der Poel, Thomas Ulas, Mark R. Mizee, Cheng-Chih Hsiao, Suzanne S. M. Miedema, Adelia, Karianne G. Schuurman, Boy Helder, Sander W. Tas, Joachim L. Schultze, Jörg Hamann, Inge Huitinga
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3dba4ae06f6a4f6d8d2e10b0073b7819
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spelling	oai:doaj.org-article:3dba4ae06f6a4f6d8d2e10b0073b78192021-12-02T17:01:55ZTranscriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes10.1038/s41467-019-08976-72041-1723https://doaj.org/article/3dba4ae06f6a4f6d8d2e10b0073b78192019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08976-7https://doaj.org/toc/2041-1723It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences in the human microglial transcriptome between grey and white matter regions, isolated from MS and non-neurological control donors, and show early microglial changes related to MS pathology.Marlijn van der PoelThomas UlasMark R. MizeeCheng-Chih HsiaoSuzanne S. M. MiedemaAdeliaKarianne G. SchuurmanBoy HelderSander W. TasJoachim L. SchultzeJörg HamannInge HuitingaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marlijn van der Poel Thomas Ulas Mark R. Mizee Cheng-Chih Hsiao Suzanne S. M. Miedema Adelia Karianne G. Schuurman Boy Helder Sander W. Tas Joachim L. Schultze Jörg Hamann Inge Huitinga Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
description	It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences in the human microglial transcriptome between grey and white matter regions, isolated from MS and non-neurological control donors, and show early microglial changes related to MS pathology.
format	article
author	Marlijn van der Poel Thomas Ulas Mark R. Mizee Cheng-Chih Hsiao Suzanne S. M. Miedema Adelia Karianne G. Schuurman Boy Helder Sander W. Tas Joachim L. Schultze Jörg Hamann Inge Huitinga
author_facet	Marlijn van der Poel Thomas Ulas Mark R. Mizee Cheng-Chih Hsiao Suzanne S. M. Miedema Adelia Karianne G. Schuurman Boy Helder Sander W. Tas Joachim L. Schultze Jörg Hamann Inge Huitinga
author_sort	Marlijn van der Poel
title	Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
title_short	Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
title_full	Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
title_fullStr	Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
title_full_unstemmed	Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
title_sort	transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3dba4ae06f6a4f6d8d2e10b0073b7819
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Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

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