Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

Abstract Metformin increased cellular ROS levels in AsPC-1 pancreatic cancer cells, with minimal effect in HDF, human primary dermal fibroblasts. Metformin reduced cellular ATP levels in HDF, but not in AsPC-1 cells. Metformin increased AMPK, p-AMPK (Thr172), FOXO3a, p-FOXO3a (Ser413), and MnSOD lev...

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Auteurs principaux: Madhuri Shende Warkad, Chea-Ha Kim, Beom-Goo Kang, Soo-Hyun Park, Jun-Sub Jung, Jing-Hui Feng, Gozde Inci, Sung-Chan Kim, Hong-Won Suh, Soon Sung Lim, Jae-Yong Lee
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/3dbbd54394c347a68799a0da2672a100
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https://doaj.org/article/3dbbd54394c347a68799a0da2672a100

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