An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.

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Detalles Bibliográficos
Autores principales: Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
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https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070

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