An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.

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Autores principales:	Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
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spelling	oai:doaj.org-article:3dc6989adc56489cbc4b3348d8eb20702021-12-02T16:43:41ZAn OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate10.1038/s41467-020-17357-42041-1723https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb20702020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17357-4https://doaj.org/toc/2041-1723OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.Jamie ZagozewskiGhazaleh M. ShahriaryLudivine Coudière MorrisonOlivier SaulnierMargaret StromeckiAgnes FresnozaGareth PalidworChristopher J. PorterAntoine ForgetOlivier AyraultCynthia HawkinsJennifer A. ChanMaria C. VladoiuLakshmikirupa SundaresanJanilyn ArsenioMichael D. TaylorVijay RamaswamyTamra E. Werbowetski-OgilvieNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jamie Zagozewski Ghazaleh M. Shahriary Ludivine Coudière Morrison Olivier Saulnier Margaret Stromecki Agnes Fresnoza Gareth Palidwor Christopher J. Porter Antoine Forget Olivier Ayrault Cynthia Hawkins Jennifer A. Chan Maria C. Vladoiu Lakshmikirupa Sundaresan Janilyn Arsenio Michael D. Taylor Vijay Ramaswamy Tamra E. Werbowetski-Ogilvie An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
description	OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
format	article
author	Jamie Zagozewski Ghazaleh M. Shahriary Ludivine Coudière Morrison Olivier Saulnier Margaret Stromecki Agnes Fresnoza Gareth Palidwor Christopher J. Porter Antoine Forget Olivier Ayrault Cynthia Hawkins Jennifer A. Chan Maria C. Vladoiu Lakshmikirupa Sundaresan Janilyn Arsenio Michael D. Taylor Vijay Ramaswamy Tamra E. Werbowetski-Ogilvie
author_facet	Jamie Zagozewski Ghazaleh M. Shahriary Ludivine Coudière Morrison Olivier Saulnier Margaret Stromecki Agnes Fresnoza Gareth Palidwor Christopher J. Porter Antoine Forget Olivier Ayrault Cynthia Hawkins Jennifer A. Chan Maria C. Vladoiu Lakshmikirupa Sundaresan Janilyn Arsenio Michael D. Taylor Vijay Ramaswamy Tamra E. Werbowetski-Ogilvie
author_sort	Jamie Zagozewski
title	An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
title_short	An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
title_full	An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
title_fullStr	An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
title_full_unstemmed	An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
title_sort	otx2-pax3 signaling axis regulates group 3 medulloblastoma cell fate
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070
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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate

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