An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate
OTX2 promotes tumour growth in Group 3 medulloblastoma. Here, the authors show that OTX2 regulates PAX3 to induce neural de-differentiation and promote tumourigenesis in Group 3 medulloblastoma.
Guardado en:
Autores principales: | Jamie Zagozewski, Ghazaleh M. Shahriary, Ludivine Coudière Morrison, Olivier Saulnier, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher J. Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer A. Chan, Maria C. Vladoiu, Lakshmikirupa Sundaresan, Janilyn Arsenio, Michael D. Taylor, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3dc6989adc56489cbc4b3348d8eb2070 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
OTX2 duplication is implicated in hemifacial microsomia.
por: Dina Zielinski, et al.
Publicado: (2014) -
The transcriptional landscape of Shh medulloblastoma
por: Patryk Skowron, et al.
Publicado: (2021) -
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
por: Jennifer Ocasio, et al.
Publicado: (2019) -
Long time to diagnosis of medulloblastoma in children is not associated with decreased survival or with worse neurological outcome.
por: Jean-Francois Brasme, et al.
Publicado: (2012) -
Wnt activation as a therapeutic strategy in medulloblastoma
por: Branavan Manoranjan, et al.
Publicado: (2020)