Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

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Detalles Bibliográficos
Autores principales: Zhihai Li, Shuo Song, Maozhou He, Daning Wang, Jingjie Shi, Xinlin Liu, Yunbing Li, Xin Chi, Shuangping Wei, Yurou Yang, Zhiping Wang, Jinjin Li, Huilian Qian, Hai Yu, Qingbing Zheng, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, Ningshao Xia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8
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https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8

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