Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhihai Li, Shuo Song, Maozhou He, Daning Wang, Jingjie Shi, Xinlin Liu, Yunbing Li, Xin Chi, Shuangping Wei, Yurou Yang, Zhiping Wang, Jinjin Li, Huilian Qian, Hai Yu, Qingbing Zheng, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, Ningshao Xia
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Internet

https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8

Documents similaires