Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

Saved in:
Bibliographic Details
Main Authors: Zhihai Li, Shuo Song, Maozhou He, Daning Wang, Jingjie Shi, Xinlin Liu, Yunbing Li, Xin Chi, Shuangping Wei, Yurou Yang, Zhiping Wang, Jinjin Li, Huilian Qian, Hai Yu, Qingbing Zheng, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, Ningshao Xia
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8

Similar Items