Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

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Autores principales: Zhihai Li, Shuo Song, Maozhou He, Daning Wang, Jingjie Shi, Xinlin Liu, Yunbing Li, Xin Chi, Shuangping Wei, Yurou Yang, Zhiping Wang, Jinjin Li, Huilian Qian, Hai Yu, Qingbing Zheng, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, Ningshao Xia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8
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spelling oai:doaj.org-article:3de48f3d69ed4d74b8bb0b144ffafdc82021-12-02T16:50:07ZRational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity10.1038/s41467-018-07199-62041-1723https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc82018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07199-6https://doaj.org/toc/2041-1723More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.Zhihai LiShuo SongMaozhou HeDaning WangJingjie ShiXinlin LiuYunbing LiXin ChiShuangping WeiYurou YangZhiping WangJinjin LiHuilian QianHai YuQingbing ZhengXiaodong YanQinjian ZhaoJun ZhangYing GuShaowei LiNingshao XiaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhihai Li
Shuo Song
Maozhou He
Daning Wang
Jingjie Shi
Xinlin Liu
Yunbing Li
Xin Chi
Shuangping Wei
Yurou Yang
Zhiping Wang
Jinjin Li
Huilian Qian
Hai Yu
Qingbing Zheng
Xiaodong Yan
Qinjian Zhao
Jun Zhang
Ying Gu
Shaowei Li
Ningshao Xia
Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
description More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.
format article
author Zhihai Li
Shuo Song
Maozhou He
Daning Wang
Jingjie Shi
Xinlin Liu
Yunbing Li
Xin Chi
Shuangping Wei
Yurou Yang
Zhiping Wang
Jinjin Li
Huilian Qian
Hai Yu
Qingbing Zheng
Xiaodong Yan
Qinjian Zhao
Jun Zhang
Ying Gu
Shaowei Li
Ningshao Xia
author_facet Zhihai Li
Shuo Song
Maozhou He
Daning Wang
Jingjie Shi
Xinlin Liu
Yunbing Li
Xin Chi
Shuangping Wei
Yurou Yang
Zhiping Wang
Jinjin Li
Huilian Qian
Hai Yu
Qingbing Zheng
Xiaodong Yan
Qinjian Zhao
Jun Zhang
Ying Gu
Shaowei Li
Ningshao Xia
author_sort Zhihai Li
title Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
title_short Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
title_full Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
title_fullStr Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
title_full_unstemmed Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
title_sort rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3de48f3d69ed4d74b8bb0b144ffafdc8
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