Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient

Calafate is a berry rich in anthocyanins that presents higher content of polyphenols than other fruits. Its compounds have been described previously, however, the potential thereof in preventing and treating degenerative disorders has not yet been studied. Due to its astringency, the consumption of...

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Autores principales:	María E. Romero-Román, Mauricio Schoebitz, Jorge Fuentealba, Cristina García-Viguera, María D. López Belchí
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anthocyanins <i>Berberis microphylla</i> encapsulation next generation ingredients PC12 cells Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3df6c758a2f9462c88da01be14e26683
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spelling	oai:doaj.org-article:3df6c758a2f9462c88da01be14e266832021-11-25T16:29:19ZPhenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient10.3390/antiox101118302076-3921https://doaj.org/article/3df6c758a2f9462c88da01be14e266832021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1830https://doaj.org/toc/2076-3921Calafate is a berry rich in anthocyanins that presents higher content of polyphenols than other fruits. Its compounds have been described previously, however, the potential thereof in preventing and treating degenerative disorders has not yet been studied. Due to its astringency, the consumption of this berry in its natural state is limited. To profit from the aforementioned properties and reduce palatability issues, calafate berry extracts were microencapsulated by spray drying, a rapid, cost-effective and scalable process, and were then compared with freeze drying as a control. The stability of its contents and its in-vitro potential, with respect to AChE activity and neuroprotection, were measured from the obtained microcapsules, resulting from temperature treatments and different encapsulant contents. The results indicated that the spray-dried powders were stable, despite high temperatures, and their encapsulation exhibited nearly 50% efficiency. The highest quantity of polyphenols and 3-<i>O</i>-glycosylated anthocyanins was obtained from encapsulation with 20% maltodextrin, at 120 °C. Temperature did not affect the microcapsules’ biological action, as demonstrated by their antioxidant activities. The prevention of Aβ peptide cytotoxicity in PC12 cells (20%) revealed that encapsulated calafate can confer neuroprotection. We conclude that spray-drying is an appropriate technique for scaling-up and producing new value-added calafate formulations with anti-neurodegenerative effects and vivid colors.María E. Romero-RománMauricio SchoebitzJorge FuentealbaCristina García-VigueraMaría D. López BelchíMDPI AGarticleanthocyanins<i>Berberis microphylla</i>encapsulationnext generation ingredientsPC12 cellsTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1830, p 1830 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anthocyanins <i>Berberis microphylla</i> encapsulation next generation ingredients PC12 cells Therapeutics. Pharmacology RM1-950
spellingShingle	anthocyanins <i>Berberis microphylla</i> encapsulation next generation ingredients PC12 cells Therapeutics. Pharmacology RM1-950 María E. Romero-Román Mauricio Schoebitz Jorge Fuentealba Cristina García-Viguera María D. López Belchí Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
description	Calafate is a berry rich in anthocyanins that presents higher content of polyphenols than other fruits. Its compounds have been described previously, however, the potential thereof in preventing and treating degenerative disorders has not yet been studied. Due to its astringency, the consumption of this berry in its natural state is limited. To profit from the aforementioned properties and reduce palatability issues, calafate berry extracts were microencapsulated by spray drying, a rapid, cost-effective and scalable process, and were then compared with freeze drying as a control. The stability of its contents and its in-vitro potential, with respect to AChE activity and neuroprotection, were measured from the obtained microcapsules, resulting from temperature treatments and different encapsulant contents. The results indicated that the spray-dried powders were stable, despite high temperatures, and their encapsulation exhibited nearly 50% efficiency. The highest quantity of polyphenols and 3-<i>O</i>-glycosylated anthocyanins was obtained from encapsulation with 20% maltodextrin, at 120 °C. Temperature did not affect the microcapsules’ biological action, as demonstrated by their antioxidant activities. The prevention of Aβ peptide cytotoxicity in PC12 cells (20%) revealed that encapsulated calafate can confer neuroprotection. We conclude that spray-drying is an appropriate technique for scaling-up and producing new value-added calafate formulations with anti-neurodegenerative effects and vivid colors.
format	article
author	María E. Romero-Román Mauricio Schoebitz Jorge Fuentealba Cristina García-Viguera María D. López Belchí
author_facet	María E. Romero-Román Mauricio Schoebitz Jorge Fuentealba Cristina García-Viguera María D. López Belchí
author_sort	María E. Romero-Román
title	Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
title_short	Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
title_full	Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
title_fullStr	Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
title_full_unstemmed	Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient
title_sort	phenolic compounds in calafate berries encapsulated by spray drying: neuroprotection potential into the ingredient
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3df6c758a2f9462c88da01be14e26683
work_keys_str_mv	AT mariaeromeroroman phenoliccompoundsincalafateberriesencapsulatedbyspraydryingneuroprotectionpotentialintotheingredient AT mauricioschoebitz phenoliccompoundsincalafateberriesencapsulatedbyspraydryingneuroprotectionpotentialintotheingredient AT jorgefuentealba phenoliccompoundsincalafateberriesencapsulatedbyspraydryingneuroprotectionpotentialintotheingredient AT cristinagarciaviguera phenoliccompoundsincalafateberriesencapsulatedbyspraydryingneuroprotectionpotentialintotheingredient AT mariadlopezbelchi phenoliccompoundsincalafateberriesencapsulatedbyspraydryingneuroprotectionpotentialintotheingredient
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Phenolic Compounds in Calafate Berries Encapsulated by Spray Drying: Neuroprotection Potential into the Ingredient

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