Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essential to mount these responses against autoantigens.

Guardado en:
Detalles Bibliográficos
Autores principales: Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!