Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essential to mount these responses against autoantigens.

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Autores principales:	Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
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spelling	oai:doaj.org-article:3e0a1f8d30674ceda6619fa064e835de2021-12-02T17:32:01ZInhibition of glucose metabolism selectively targets autoreactive follicular helper T cells10.1038/s41467-018-06686-02041-1723https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06686-0https://doaj.org/toc/2041-1723T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essential to mount these responses against autoantigens.Seung-Chul ChoiAnton A. TitovGeorges AbboudHoward R. SeayTodd M. BruskoDerry C. RoopenianShahram Salek-ArdakaniLaurence MorelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung-Chul Choi Anton A. Titov Georges Abboud Howard R. Seay Todd M. Brusko Derry C. Roopenian Shahram Salek-Ardakani Laurence Morel Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
description	T cell functions depend on distinct metabolic fluxes. Here the authors show different metabolic requirements of humoral responses to self versus microbial antigens: while glucose is dispensable for antiviral Tfh and antibody responses, it is essential to mount these responses against autoantigens.
format	article
author	Seung-Chul Choi Anton A. Titov Georges Abboud Howard R. Seay Todd M. Brusko Derry C. Roopenian Shahram Salek-Ardakani Laurence Morel
author_facet	Seung-Chul Choi Anton A. Titov Georges Abboud Howard R. Seay Todd M. Brusko Derry C. Roopenian Shahram Salek-Ardakani Laurence Morel
author_sort	Seung-Chul Choi
title	Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
title_short	Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
title_full	Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
title_fullStr	Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
title_full_unstemmed	Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells
title_sort	inhibition of glucose metabolism selectively targets autoreactive follicular helper t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3e0a1f8d30674ceda6619fa064e835de
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Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

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