LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.

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Detalles Bibliográficos
Autores principales: María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
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https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae

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