LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.

Guardado en:

Detalles Bibliográficos
Autores principales:	María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e0ce24ca18642ab920706ba35de6dae
record_format	dspace
spelling	oai:doaj.org-article:3e0ce24ca18642ab920706ba35de6dae2021-12-02T17:01:56ZLRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells10.1038/s41467-021-22813-w2041-1723https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22813-whttps://doaj.org/toc/2041-1723How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.María Ángeles Marqués-TorrejónCharles A. C. WilliamsBenjamin SouthgateNeza AlfazemaMelanie P. ClementsClaudia Garcia-DiazCarla BlinNerea Arranz-EmparanJane FraserNoor GammohSimona ParrinelloSteven M. PollardNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q María Ángeles Marqués-Torrejón Charles A. C. Williams Benjamin Southgate Neza Alfazema Melanie P. Clements Claudia Garcia-Diaz Carla Blin Nerea Arranz-Emparan Jane Fraser Noor Gammoh Simona Parrinello Steven M. Pollard LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
description	How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via modulation of the EGFR pathway.
format	article
author	María Ángeles Marqués-Torrejón Charles A. C. Williams Benjamin Southgate Neza Alfazema Melanie P. Clements Claudia Garcia-Diaz Carla Blin Nerea Arranz-Emparan Jane Fraser Noor Gammoh Simona Parrinello Steven M. Pollard
author_facet	María Ángeles Marqués-Torrejón Charles A. C. Williams Benjamin Southgate Neza Alfazema Melanie P. Clements Claudia Garcia-Diaz Carla Blin Nerea Arranz-Emparan Jane Fraser Noor Gammoh Simona Parrinello Steven M. Pollard
author_sort	María Ángeles Marqués-Torrejón
title	LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_short	LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_full	LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_fullStr	LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_full_unstemmed	LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells
title_sort	lrig1 is a gatekeeper to exit from quiescence in adult neural stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
work_keys_str_mv	AT mariaangelesmarquestorrejon lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT charlesacwilliams lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT benjaminsouthgate lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT nezaalfazema lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT melaniepclements lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT claudiagarciadiaz lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT carlablin lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT nereaarranzemparan lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT janefraser lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT noorgammoh lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT simonaparrinello lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells AT stevenmpollard lrig1isagatekeepertoexitfromquiescenceinadultneuralstemcells
_version_	1718381961825746944

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

Ejemplares similares