Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights into the structural changes that lead to PARP2 activat...

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Autores principales: Ezeogo Obaji, Mirko M. Maksimainen, Albert Galera-Prat, Lari Lehtiö
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f
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