Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights into the structural changes that lead to PARP2 activat...

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Autores principales:	Ezeogo Obaji, Mirko M. Maksimainen, Albert Galera-Prat, Lari Lehtiö
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f
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spelling	oai:doaj.org-article:3e12a12ec89744fea3a04b2b30548e8f2021-12-02T14:59:27ZActivation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition10.1038/s41467-021-23800-x2041-1723https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23800-xhttps://doaj.org/toc/2041-1723Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights into the structural changes that lead to PARP2 activation.Ezeogo ObajiMirko M. MaksimainenAlbert Galera-PratLari LehtiöNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ezeogo Obaji Mirko M. Maksimainen Albert Galera-Prat Lari Lehtiö Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
description	Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights into the structural changes that lead to PARP2 activation.
format	article
author	Ezeogo Obaji Mirko M. Maksimainen Albert Galera-Prat Lari Lehtiö
author_facet	Ezeogo Obaji Mirko M. Maksimainen Albert Galera-Prat Lari Lehtiö
author_sort	Ezeogo Obaji
title	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
title_short	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
title_full	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
title_fullStr	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
title_full_unstemmed	Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
title_sort	activation of parp2/artd2 by dna damage induces conformational changes relieving enzyme autoinhibition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f
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Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

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