Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.

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Bibliographic Details
Main Authors: Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
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https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6

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