Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.

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Autores principales:	Ulrich Pfisterer, Viktor Petukhov, Samuel Demharter, Johanna Meichsner, Jonatan J. Thompson, Mykhailo Y. Batiuk, Andrea Asenjo-Martinez, Navneet A. Vasistha, Ashish Thakur, Jens Mikkelsen, Istvan Adorjan, Lars H. Pinborg, Tune H. Pers, Jakob von Engelhardt, Peter V. Kharchenko, Konstantin Khodosevich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
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spelling	oai:doaj.org-article:3e192b5fa2834006a330d7be93363fc62021-12-02T16:56:44ZIdentification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis10.1038/s41467-020-18752-72041-1723https://doaj.org/article/3e192b5fa2834006a330d7be93363fc62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18752-7https://doaj.org/toc/2041-1723The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.Ulrich PfistererViktor PetukhovSamuel DemharterJohanna MeichsnerJonatan J. ThompsonMykhailo Y. BatiukAndrea Asenjo-MartinezNavneet A. VasisthaAshish ThakurJens MikkelsenIstvan AdorjanLars H. PinborgTune H. PersJakob von EngelhardtPeter V. KharchenkoKonstantin KhodosevichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ulrich Pfisterer Viktor Petukhov Samuel Demharter Johanna Meichsner Jonatan J. Thompson Mykhailo Y. Batiuk Andrea Asenjo-Martinez Navneet A. Vasistha Ashish Thakur Jens Mikkelsen Istvan Adorjan Lars H. Pinborg Tune H. Pers Jakob von Engelhardt Peter V. Kharchenko Konstantin Khodosevich Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
description	The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.
format	article
author	Ulrich Pfisterer Viktor Petukhov Samuel Demharter Johanna Meichsner Jonatan J. Thompson Mykhailo Y. Batiuk Andrea Asenjo-Martinez Navneet A. Vasistha Ashish Thakur Jens Mikkelsen Istvan Adorjan Lars H. Pinborg Tune H. Pers Jakob von Engelhardt Peter V. Kharchenko Konstantin Khodosevich
author_facet	Ulrich Pfisterer Viktor Petukhov Samuel Demharter Johanna Meichsner Jonatan J. Thompson Mykhailo Y. Batiuk Andrea Asenjo-Martinez Navneet A. Vasistha Ashish Thakur Jens Mikkelsen Istvan Adorjan Lars H. Pinborg Tune H. Pers Jakob von Engelhardt Peter V. Kharchenko Konstantin Khodosevich
author_sort	Ulrich Pfisterer
title	Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
title_short	Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
title_full	Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
title_fullStr	Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
title_full_unstemmed	Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
title_sort	identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3e192b5fa2834006a330d7be93363fc6
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Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

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