A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Abstract A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes. By specifically labeling the disulfide bridge this molecule becomes accessible for analytic...

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Autores principales: Kevin Herr, Max Fleckenstein, Martin Brodrecht, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Torsten Gutmann, Michael Reggelin, Gerd Buntkowsky
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3e3cc9a70aab41148a91c6390f29b657
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