Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini

Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome alterations, but the mechanism of their formation remains unclear. Here the authors find that DNA polymerase α primase plays part in tandem duplication formation at CRISPR/Cas9-induced complementary 3′...

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Autores principales: Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Marcel Tijsterman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3e3f130d195f4ae0b99ff4a7f386fe74
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