Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini

Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome alterations, but the mechanism of their formation remains unclear. Here the authors find that DNA polymerase α primase plays part in tandem duplication formation at CRISPR/Cas9-induced complementary 3′...

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Autores principales:	Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Marcel Tijsterman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3e3f130d195f4ae0b99ff4a7f386fe74
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spelling	oai:doaj.org-article:3e3f130d195f4ae0b99ff4a7f386fe742021-12-02T15:07:49ZSmall tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini10.1038/s41467-021-25154-w2041-1723https://doaj.org/article/3e3f130d195f4ae0b99ff4a7f386fe742021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25154-whttps://doaj.org/toc/2041-1723Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome alterations, but the mechanism of their formation remains unclear. Here the authors find that DNA polymerase α primase plays part in tandem duplication formation at CRISPR/Cas9-induced complementary 3′ ssDNA protrusions.Joost SchimmelNúria Muñoz-SubiranaHanneke KoolRobin van SchendelMarcel TijstermanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Marcel Tijsterman Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
description	Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome alterations, but the mechanism of their formation remains unclear. Here the authors find that DNA polymerase α primase plays part in tandem duplication formation at CRISPR/Cas9-induced complementary 3′ ssDNA protrusions.
format	article
author	Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Marcel Tijsterman
author_facet	Joost Schimmel Núria Muñoz-Subirana Hanneke Kool Robin van Schendel Marcel Tijsterman
author_sort	Joost Schimmel
title	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
title_short	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
title_full	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
title_fullStr	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
title_full_unstemmed	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
title_sort	small tandem dna duplications result from cst-guided pol α-primase action at dna break termini
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3e3f130d195f4ae0b99ff4a7f386fe74
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Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini

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