YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP-1 family) and STAT3, key transcription factors that mediate an epigenetic switch linking inflammation to cellular trans...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lizhi He, Henry Pratt, Mingshi Gao, Fengxiang Wei, Zhiping Weng, Kevin Struhl
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	transcriptional co-activator cellular transformation gene regulation YAP TAZ cancer Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3e3ffdd2b83944b3af6bdbc7d2c096f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3e3ffdd2b83944b3af6bdbc7d2c096f9
record_format	dspace
spelling	oai:doaj.org-article:3e3ffdd2b83944b3af6bdbc7d2c096f92021-11-15T06:47:29ZYAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation10.7554/eLife.673122050-084Xe67312https://doaj.org/article/3e3ffdd2b83944b3af6bdbc7d2c096f92021-08-01T00:00:00Zhttps://elifesciences.org/articles/67312https://doaj.org/toc/2050-084XThe YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP-1 family) and STAT3, key transcription factors that mediate an epigenetic switch linking inflammation to cellular transformation. YAP and TAZ directly interact with JUNB and STAT3 via a WW domain important for transformation, and they stimulate transcriptional activation by AP-1 proteins. JUNB, STAT3, and TEAD co-localize at virtually all YAP/TAZ target sites, yet many target sites only contain individual AP-1, TEAD, or STAT3 motifs. This observation and differences in relative crosslinking efficiencies of JUNB, TEAD, and STAT3 at YAP/TAZ target sites suggest that YAP/TAZ is recruited by different forms of an AP-1/STAT3/TEAD complex depending on the recruiting motif. The different classes of YAP/TAZ target sites are associated with largely non-overlapping genes with distinct functions. A small minority of target sites are YAP- or TAZ-specific, and they are associated with different sequence motifs and gene classes from shared YAP/TAZ target sites. Genes containing either the AP-1 or TEAD class of YAP/TAZ sites are associated with poor survival of breast cancer patients with the triple-negative form of the disease.Lizhi HeHenry PrattMingshi GaoFengxiang WeiZhiping WengKevin StruhleLife Sciences Publications Ltdarticletranscriptional co-activatorcellular transformationgene regulationYAPTAZcancerMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcriptional co-activator cellular transformation gene regulation YAP TAZ cancer Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	transcriptional co-activator cellular transformation gene regulation YAP TAZ cancer Medicine R Science Q Biology (General) QH301-705.5 Lizhi He Henry Pratt Mingshi Gao Fengxiang Wei Zhiping Weng Kevin Struhl YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
description	The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP-1 family) and STAT3, key transcription factors that mediate an epigenetic switch linking inflammation to cellular transformation. YAP and TAZ directly interact with JUNB and STAT3 via a WW domain important for transformation, and they stimulate transcriptional activation by AP-1 proteins. JUNB, STAT3, and TEAD co-localize at virtually all YAP/TAZ target sites, yet many target sites only contain individual AP-1, TEAD, or STAT3 motifs. This observation and differences in relative crosslinking efficiencies of JUNB, TEAD, and STAT3 at YAP/TAZ target sites suggest that YAP/TAZ is recruited by different forms of an AP-1/STAT3/TEAD complex depending on the recruiting motif. The different classes of YAP/TAZ target sites are associated with largely non-overlapping genes with distinct functions. A small minority of target sites are YAP- or TAZ-specific, and they are associated with different sequence motifs and gene classes from shared YAP/TAZ target sites. Genes containing either the AP-1 or TEAD class of YAP/TAZ sites are associated with poor survival of breast cancer patients with the triple-negative form of the disease.
format	article
author	Lizhi He Henry Pratt Mingshi Gao Fengxiang Wei Zhiping Weng Kevin Struhl
author_facet	Lizhi He Henry Pratt Mingshi Gao Fengxiang Wei Zhiping Weng Kevin Struhl
author_sort	Lizhi He
title	YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
title_short	YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
title_full	YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
title_fullStr	YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
title_full_unstemmed	YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation
title_sort	yap and taz are transcriptional co-activators of ap-1 proteins and stat3 during breast cellular transformation
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/3e3ffdd2b83944b3af6bdbc7d2c096f9
work_keys_str_mv	AT lizhihe yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation AT henrypratt yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation AT mingshigao yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation AT fengxiangwei yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation AT zhipingweng yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation AT kevinstruhl yapandtazaretranscriptionalcoactivatorsofap1proteinsandstat3duringbreastcellulartransformation
_version_	1718428546310864896

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

Ejemplares similares