Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity
Abstract Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal horn (SDH) requires further study. We used chronic BDNF treatment (200 ng/ml, 5–6 ...
Guardado en:
Autores principales: | Sascha R. A. Alles, Max A. Odem, Van B. Lu, Ryan M. Cassidy, Peter A. Smith |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/3e69283edd694e9888f90e726ca6e55a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Neuron-specific spinal cord translatomes reveal a neuropeptide code for mouse dorsal horn excitatory neurons
por: Rebecca Rani Das Gupta, et al.
Publicado: (2021) -
Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn
por: Alexander Chamessian, et al.
Publicado: (2018) -
Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain
por: Takahiro Masuda, et al.
Publicado: (2016) -
Neuron Type-Dependent Synaptic Activity in the Spinal Dorsal Horn of Opioid-Induced Hyperalgesia Mouse Model
por: Austin Kearns, et al.
Publicado: (2021) -
Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn
por: Mario Heles, et al.
Publicado: (2021)