Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

Abstract Brain-derived neurotrophic factor (BDNF) is critically involved in the pathophysiology of chronic pain. However, the mechanisms of BDNF action on specific neuronal populations in the spinal superficial dorsal horn (SDH) requires further study. We used chronic BDNF treatment (200 ng/ml, 5–6 ...

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Bibliographic Details
Main Authors: Sascha R. A. Alles, Max A. Odem, Van B. Lu, Ryan M. Cassidy, Peter A. Smith
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/3e69283edd694e9888f90e726ca6e55a
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