Induction of mitochondria-mediated apoptosis and suppression of tumor growth in zebrafish xenograft model by cyclic dipeptides identified from Exiguobacterium acetylicum

Abstract Colorectal cancer is the most common type of gastrointestinal cancers with poor survival and limited therapeutic options. In this study, four structurally different cyclic dipeptides (or diketopiperazine) were isolated and identified as cyclo (l-Pro-l-Leu), cyclo (l-Pro-l-Val), cyclo (l-Pro...

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Autores principales: Sekar Jinendiran, Weilin Teng, Hans-Uwe Dahms, Wangta Liu, Vinoth Kumar Ponnusamy, Charles Chien-Chih Chiu, B. S. Dileep Kumar, Natesan Sivakumar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/3ea8fd1054ec4ab8b0b59360c98cf452
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