Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans

Current methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.

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Autores principales:	Hye Ryoung Heo, Kye Il Joo, Jeong Hyun Seo, Chang Sup Kim, Hyung Joon Cha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eb2ecbd5a8b4c19b5c913abf739dbae
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spelling	oai:doaj.org-article:3eb2ecbd5a8b4c19b5c913abf739dbae2021-12-02T13:34:55ZGlycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans10.1038/s41467-021-21538-02041-1723https://doaj.org/article/3eb2ecbd5a8b4c19b5c913abf739dbae2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21538-0https://doaj.org/toc/2041-1723Current methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.Hye Ryoung HeoKye Il JooJeong Hyun SeoChang Sup KimHyung Joon ChaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
description	Current methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.
format	article
author	Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha
author_facet	Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha
author_sort	Hye Ryoung Heo
title	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_short	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_full	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_fullStr	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_full_unstemmed	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_sort	glycan chip based on structure-switchable dna linker for on-chip biosynthesis of cancer-associated complex glycans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3eb2ecbd5a8b4c19b5c913abf739dbae
work_keys_str_mv	AT hyeryoungheo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT kyeiljoo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT jeonghyunseo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT changsupkim glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT hyungjooncha glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans
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Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans

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