Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, p...

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Autores principales:	Caroline P. Le, Cameron J. Nowell, Corina Kim-Fuchs, Edoardo Botteri, Jonathan G. Hiller, Hilmy Ismail, Matthew A. Pimentel, Ming G. Chai, Tara Karnezis, Nicole Rotmensz, Giuseppe Renne, Sara Gandini, Colin W. Pouton, Davide Ferrari, Andreas Möller, Steven A. Stacker, Erica K. Sloan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eb5ab2a6c134a019c85df9430bef9cf
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spelling	oai:doaj.org-article:3eb5ab2a6c134a019c85df9430bef9cf2021-12-02T17:33:21ZChronic stress in mice remodels lymph vasculature to promote tumour cell dissemination10.1038/ncomms106342041-1723https://doaj.org/article/3eb5ab2a6c134a019c85df9430bef9cf2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10634https://doaj.org/toc/2041-1723Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis.Caroline P. LeCameron J. NowellCorina Kim-FuchsEdoardo BotteriJonathan G. HillerHilmy IsmailMatthew A. PimentelMing G. ChaiTara KarnezisNicole RotmenszGiuseppe RenneSara GandiniColin W. PoutonDavide FerrariAndreas MöllerSteven A. StackerErica K. SloanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline P. Le Cameron J. Nowell Corina Kim-Fuchs Edoardo Botteri Jonathan G. Hiller Hilmy Ismail Matthew A. Pimentel Ming G. Chai Tara Karnezis Nicole Rotmensz Giuseppe Renne Sara Gandini Colin W. Pouton Davide Ferrari Andreas Möller Steven A. Stacker Erica K. Sloan Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
description	Adverse life events have been associated with reduced survival in cancer patients. Here, the authors explore the mechanism responsible and show that chronic stress in mice activates a signalling cascade in macrophages and tumour cells, which results in restructuring of the tumour lymphatic system, promoting metastasis.
format	article
author	Caroline P. Le Cameron J. Nowell Corina Kim-Fuchs Edoardo Botteri Jonathan G. Hiller Hilmy Ismail Matthew A. Pimentel Ming G. Chai Tara Karnezis Nicole Rotmensz Giuseppe Renne Sara Gandini Colin W. Pouton Davide Ferrari Andreas Möller Steven A. Stacker Erica K. Sloan
author_facet	Caroline P. Le Cameron J. Nowell Corina Kim-Fuchs Edoardo Botteri Jonathan G. Hiller Hilmy Ismail Matthew A. Pimentel Ming G. Chai Tara Karnezis Nicole Rotmensz Giuseppe Renne Sara Gandini Colin W. Pouton Davide Ferrari Andreas Möller Steven A. Stacker Erica K. Sloan
author_sort	Caroline P. Le
title	Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
title_short	Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
title_full	Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
title_fullStr	Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
title_full_unstemmed	Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
title_sort	chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3eb5ab2a6c134a019c85df9430bef9cf
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Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

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