Asynchronous suppression of visual cortex during absence seizures in stargazer mice

Absence epilepsy is associated with frequent generalized spike-wave seizures and loss of awareness. Here the authors use 2-photon calcium imaging of primary visual cortex in a genetic mouse model of absence epilepsy and find that cortical neurons are less active and more loosely coupled to the seizu...

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Bibliographic Details
Main Authors: Jochen Meyer, Atul Maheshwari, Jeffrey Noebels, Stelios Smirnakis
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/3ebcd068ba1946c5b3c29784c6bf764e
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Summary:Absence epilepsy is associated with frequent generalized spike-wave seizures and loss of awareness. Here the authors use 2-photon calcium imaging of primary visual cortex in a genetic mouse model of absence epilepsy and find that cortical neurons are less active and more loosely coupled to the seizure EEG signature than previously believed.