Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or...

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Autores principales: Nikolay Burnaevskiy, Bryan Sands, Soo Yun, Patricia M. Tedesco, Thomas E. Johnson, Matt Kaeberlein, Roger Brent, Alexander Mendenhall
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3eca43d27d3a4ec0ac746c9204fa7760
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