Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or...

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Autores principales:	Nikolay Burnaevskiy, Bryan Sands, Soo Yun, Patricia M. Tedesco, Thomas E. Johnson, Matt Kaeberlein, Roger Brent, Alexander Mendenhall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3eca43d27d3a4ec0ac746c9204fa7760
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spelling	oai:doaj.org-article:3eca43d27d3a4ec0ac746c9204fa77602021-12-02T15:35:17ZChaperone biomarkers of lifespan and penetrance track the dosages of many other proteins10.1038/s41467-019-13664-72041-1723https://doaj.org/article/3eca43d27d3a4ec0ac746c9204fa77602019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13664-7https://doaj.org/toc/2041-1723In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.Nikolay BurnaevskiyBryan SandsSoo YunPatricia M. TedescoThomas E. JohnsonMatt KaeberleinRoger BrentAlexander MendenhallNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolay Burnaevskiy Bryan Sands Soo Yun Patricia M. Tedesco Thomas E. Johnson Matt Kaeberlein Roger Brent Alexander Mendenhall Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
description	In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.
format	article
author	Nikolay Burnaevskiy Bryan Sands Soo Yun Patricia M. Tedesco Thomas E. Johnson Matt Kaeberlein Roger Brent Alexander Mendenhall
author_facet	Nikolay Burnaevskiy Bryan Sands Soo Yun Patricia M. Tedesco Thomas E. Johnson Matt Kaeberlein Roger Brent Alexander Mendenhall
author_sort	Nikolay Burnaevskiy
title	Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
title_short	Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
title_full	Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
title_fullStr	Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
title_full_unstemmed	Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
title_sort	chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3eca43d27d3a4ec0ac746c9204fa7760
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Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

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