Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.

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Autores principales:	Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71
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spelling	oai:doaj.org-article:3f361bf123134e9fb806b778a2f53c712021-12-02T14:39:35ZEnhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle10.1038/s41467-019-12080-12041-1723https://doaj.org/article/3f361bf123134e9fb806b778a2f53c712019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12080-1https://doaj.org/toc/2041-1723Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.Philip J. M. BrouwerAleksandar AntanasijevicZachary BerndsenAnila YasmeenBrooke FialaTom P. L. BijlIlja BontjerJacob B. BaleWilliam ShefflerJoel D. AllenAnna SchorchtJudith A. BurgerMiguel CamachoDaniel EllisChristopher A. CottrellAnna-Janina BehrensMarco CatalanoIván del Moral-SánchezThomas J. KetasCelia LaBrancheMarit J. van GilsKwinten SliepenLance J. StewartMax CrispinDavid C. MontefioriDavid BakerJohn P. MoorePer Johan KlasseAndrew B. WardNeil P. KingRogier W. SandersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Philip J. M. Brouwer Aleksandar Antanasijevic Zachary Berndsen Anila Yasmeen Brooke Fiala Tom P. L. Bijl Ilja Bontjer Jacob B. Bale William Sheffler Joel D. Allen Anna Schorcht Judith A. Burger Miguel Camacho Daniel Ellis Christopher A. Cottrell Anna-Janina Behrens Marco Catalano Iván del Moral-Sánchez Thomas J. Ketas Celia LaBranche Marit J. van Gils Kwinten Sliepen Lance J. Stewart Max Crispin David C. Montefiori David Baker John P. Moore Per Johan Klasse Andrew B. Ward Neil P. King Rogier W. Sanders Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
description	Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.
format	article
author	Philip J. M. Brouwer Aleksandar Antanasijevic Zachary Berndsen Anila Yasmeen Brooke Fiala Tom P. L. Bijl Ilja Bontjer Jacob B. Bale William Sheffler Joel D. Allen Anna Schorcht Judith A. Burger Miguel Camacho Daniel Ellis Christopher A. Cottrell Anna-Janina Behrens Marco Catalano Iván del Moral-Sánchez Thomas J. Ketas Celia LaBranche Marit J. van Gils Kwinten Sliepen Lance J. Stewart Max Crispin David C. Montefiori David Baker John P. Moore Per Johan Klasse Andrew B. Ward Neil P. King Rogier W. Sanders
author_facet	Philip J. M. Brouwer Aleksandar Antanasijevic Zachary Berndsen Anila Yasmeen Brooke Fiala Tom P. L. Bijl Ilja Bontjer Jacob B. Bale William Sheffler Joel D. Allen Anna Schorcht Judith A. Burger Miguel Camacho Daniel Ellis Christopher A. Cottrell Anna-Janina Behrens Marco Catalano Iván del Moral-Sánchez Thomas J. Ketas Celia LaBranche Marit J. van Gils Kwinten Sliepen Lance J. Stewart Max Crispin David C. Montefiori David Baker John P. Moore Per Johan Klasse Andrew B. Ward Neil P. King Rogier W. Sanders
author_sort	Philip J. M. Brouwer
title	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
title_short	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
title_full	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
title_fullStr	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
title_full_unstemmed	Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
title_sort	enhancing and shaping the immunogenicity of native-like hiv-1 envelope trimers with a two-component protein nanoparticle
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71
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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

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