Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immunogenicity in a small animal model.

Guardado en:

Detalles Bibliográficos
Autores principales:	Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary Berndsen, Anila Yasmeen, Brooke Fiala, Tom P. L. Bijl, Ilja Bontjer, Jacob B. Bale, William Sheffler, Joel D. Allen, Anna Schorcht, Judith A. Burger, Miguel Camacho, Daniel Ellis, Christopher A. Cottrell, Anna-Janina Behrens, Marco Catalano, Iván del Moral-Sánchez, Thomas J. Ketas, Celia LaBranche, Marit J. van Gils, Kwinten Sliepen, Lance J. Stewart, Max Crispin, David C. Montefiori, David Baker, John P. Moore, Per Johan Klasse, Andrew B. Ward, Neil P. King, Rogier W. Sanders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f361bf123134e9fb806b778a2f53c71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Sea el primero en dejar un comentario!

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Ejemplares similares