The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries reducing metastasis and cancer progression.

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Bibliographic Details
Main Authors: Silvia Grasso, Jennifer Chapelle, Vincenzo Salemme, Simona Aramu, Isabella Russo, Nicoletta Vitale, Ludovica Verdun di Cantogno, Katiuscia Dallaglio, Isabella Castellano, Augusto Amici, Giorgia Centonze, Nanaocha Sharma, Serena Lunardi, Sara Cabodi, Federica Cavallo, Alessia Lamolinara, Lorenzo Stramucci, Enrico Moiso, Paolo Provero, Adriana Albini, Anna Sapino, Johan Staaf, Pier Paolo Di Fiore, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Manuela Iezzi, Paola Di Stefano, Emilia Turco, Paola Defilippi
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
Q
Online Access:https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a7
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