Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty liver disease.

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Auteurs principaux: Troy L. Merry, Chris P. Hedges, Stewart W. Masson, Beate Laube, Doris Pöhlmann, Stephan Wueest, Michael E. Walsh, Myrtha Arnold, Wolfgang Langhans, Daniel Konrad, Kim Zarse, Michael Ristow
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b5
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