Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty liver disease.

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Autores principales:	Troy L. Merry, Chris P. Hedges, Stewart W. Masson, Beate Laube, Doris Pöhlmann, Stephan Wueest, Michael E. Walsh, Myrtha Arnold, Wolfgang Langhans, Daniel Konrad, Kim Zarse, Michael Ristow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b5
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spelling	oai:doaj.org-article:3f677e3dd7d8427a94a17c5f51b1a7b52021-12-02T17:32:57ZPartial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease10.1038/s41467-020-15623-z2041-1723https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15623-zhttps://doaj.org/toc/2041-1723Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty liver disease.Troy L. MerryChris P. HedgesStewart W. MassonBeate LaubeDoris PöhlmannStephan WueestMichael E. WalshMyrtha ArnoldWolfgang LanghansDaniel KonradKim ZarseMichael RistowNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Troy L. Merry Chris P. Hedges Stewart W. Masson Beate Laube Doris Pöhlmann Stephan Wueest Michael E. Walsh Myrtha Arnold Wolfgang Langhans Daniel Konrad Kim Zarse Michael Ristow Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
description	Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty liver disease.
format	article
author	Troy L. Merry Chris P. Hedges Stewart W. Masson Beate Laube Doris Pöhlmann Stephan Wueest Michael E. Walsh Myrtha Arnold Wolfgang Langhans Daniel Konrad Kim Zarse Michael Ristow
author_facet	Troy L. Merry Chris P. Hedges Stewart W. Masson Beate Laube Doris Pöhlmann Stephan Wueest Michael E. Walsh Myrtha Arnold Wolfgang Langhans Daniel Konrad Kim Zarse Michael Ristow
author_sort	Troy L. Merry
title	Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
title_short	Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
title_full	Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
title_fullStr	Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
title_full_unstemmed	Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
title_sort	partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b5
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Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease

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