Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after trans...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amy Y. Clark, Karen E. Martin, José R. García, Christopher T. Johnson, Hannah S. Theriault, Woojin M. Han, Dennis W. Zhou, Edward A. Botchwey, Andrés J. García
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3fd09731be6146368f5826555738dc7e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3fd09731be6146368f5826555738dc7e
record_format	dspace
spelling	oai:doaj.org-article:3fd09731be6146368f5826555738dc7e2021-12-02T14:41:03ZIntegrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities10.1038/s41467-019-14000-92041-1723https://doaj.org/article/3fd09731be6146368f5826555738dc7e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14000-9https://doaj.org/toc/2041-1723Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after transplant, as well as bone repair.Amy Y. ClarkKaren E. MartinJosé R. GarcíaChristopher T. JohnsonHannah S. TheriaultWoojin M. HanDennis W. ZhouEdward A. BotchweyAndrés J. GarcíaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
description	Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after transplant, as well as bone repair.
format	article
author	Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García
author_facet	Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García
author_sort	Amy Y. Clark
title	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_short	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_full	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_fullStr	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_full_unstemmed	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_sort	integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3fd09731be6146368f5826555738dc7e
work_keys_str_mv	AT amyyclark integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT karenemartin integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT josergarcia integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT christophertjohnson integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT hannahstheriault integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT woojinmhan integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT denniswzhou integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT edwardabotchwey integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities AT andresjgarcia integrinspecifichydrogelsmodulatetransplantedhumanbonemarrowderivedmesenchymalstemcellsurvivalengraftmentandreparativeactivities
_version_	1718390047113216000

Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

Ejemplares similares