Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after trans...

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Auteurs principaux:	Amy Y. Clark, Karen E. Martin, José R. García, Christopher T. Johnson, Hannah S. Theriault, Woojin M. Han, Dennis W. Zhou, Edward A. Botchwey, Andrés J. García
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3fd09731be6146368f5826555738dc7e
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spelling	oai:doaj.org-article:3fd09731be6146368f5826555738dc7e2021-12-02T14:41:03ZIntegrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities10.1038/s41467-019-14000-92041-1723https://doaj.org/article/3fd09731be6146368f5826555738dc7e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14000-9https://doaj.org/toc/2041-1723Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after transplant, as well as bone repair.Amy Y. ClarkKaren E. MartinJosé R. GarcíaChristopher T. JohnsonHannah S. TheriaultWoojin M. HanDennis W. ZhouEdward A. BotchweyAndrés J. GarcíaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
description	Mesenchymal stromal cells enhance bone and cartilage repair, but are limited by poor survival and retention after transplantation. Here, the authors show that synthetic hydrogels presenting integrin-specific peptides enhance the survival and persistence of human mesenchymal stromal cells after transplant, as well as bone repair.
format	article
author	Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García
author_facet	Amy Y. Clark Karen E. Martin José R. García Christopher T. Johnson Hannah S. Theriault Woojin M. Han Dennis W. Zhou Edward A. Botchwey Andrés J. García
author_sort	Amy Y. Clark
title	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_short	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_full	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_fullStr	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_full_unstemmed	Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
title_sort	integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3fd09731be6146368f5826555738dc7e
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Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

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